交医生命科学中心 (交一生物材料与再生医学技术中心)

交一生物材料与再生医学技术中心专注于自体细胞与生物墨水在再生医学领域的研究与应用。作为一种前沿的医学技术，自体细胞能够通过重新编程和分化，实现人体组织的再生与修复。而生物墨水则是一种含有活体细胞和生物材料的可注入液体，用于3D打印人体组织和器官。

中心的研究团队致力于开发先进的自体细胞分离、培养和扩增技术，以提高自体细胞在再生医学中的应用效果。同时，中心还研究设计创新的生物墨水，以解决人工器官和组织移植中的供给问题。

中心与多家医疗机构、科研院所和企业展开合作，共同推动相关技术的发展和转化。通过深入了解人体生物学特性和创新技术的应用，中心为实现个性化医疗和器官再生提供了有力的支持。

中心的目标是在自体细胞和生物墨水研究方面取得突破性的进展，并将其应用于各种再生医学领域，包括组织工程、器官再生和药物筛选。通过跨学科的合作和持续创新，中心致力于为人类健康和医学进步做出贡献。

刘昌胜 1967年6月出生于湖北大冶，生物材料学家，中国科学院院士，华东理工大学教授、博士生导师，上海大学校长、党委副书记 。 长期从事生物材料的研究，发展了多种活性骨修复材料以及生长因子制备和材料活化新技术；研制出自固化磷酸钙人工骨并获此类产品注册证，实现临床广泛应用。 刘昌胜提出了仿生人体创伤自愈合过程、构建材料在体内引导组织原位再生的学术思路，利用材料在体内所激发的系列生物学效应， 实现无生命材料向有生命组织的转化。研制出自固化磷酸钙人工骨，实现了准确塑形、生物降解、同步成骨特性统一，获国家药监局该类产品首张注册证， 已广泛应用于临床。发明了制备人骨生长因子和材料活性化的新方法，研制出活性骨修复体已应用于临床，取得了满意的治疗效果 。 

学术论著 截至2017年11月，刘昌胜出版著作（教材）4部，发表SCI论文201篇，包括在生物材料领域权威期刊Biomaterials（生物材料）上发表21篇，以及在Chemical Reviews（化学评论）等学术杂志上发表的多篇论文。

Jinyang Li, Xue Qu, Gregory F. Payne, Cheng Zhang, Yuxin Zhang, Jianbo Li, Jie Ren, Hua Hong, Changsheng Liu, Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery, Adv. Funct. Mater. 2015. Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing, Changsheng Liu, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2, Biomaterials, 2014, 35(2):684-698. Lingyan Cao, Jerome A. Werkmeister, Jing Wang, Veronica Glattauer, Keith M. McLean*, Changsheng Liu*, Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles, Biomaterials, 2014,35(9): 2730-2742. Fan Yang, Jing Wang, Juan Hou, Han Guo, Changsheng Liu, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2, Biomaterials, 2013, 34: 1514-1528. Jing Zhang, Huanjun Zhou, Kai Yang, Yuan Yuan*, Changsheng Liu*, RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 2013, 34: 9381-9392. Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang, Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds, Tissue Engineering Part A, 2012, 18(1-2): 185-197. Deliang Zeng, Lunguo Xia, Wenjie Zhang, Hui Huang, Bin Wei, Qingfeng Huang, Jie Wei, Changsheng Liu, Xinquan Jiang, Maxillary Sinus Floor Elevation Using a Tissue-Engineered Bone with Calcium-Magnesium Phosphate Cement and Bone Marrow Stromal Cells in Rabbits, Tissue Engineering Part A, 2012, 18(7-8): 870-882. Derong Zou, Lian Guo, Jiayu Lu, Xiuli Zhang, Jie Wei, Changsheng Liu, Zhiyuan Zhang, Xinquan Jiang, Engineering of Bone Using Porous Calcium Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats, Tissue Engineering Part A, 2012, 18(13-14): 1464-1478. Chenglong Dai, Han Guo, Jingxiong Lu, Jianlin Shi, Jie Wei, Changsheng Liu*, Osteogenic evaluation of calcium/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2 by synchrotron radiation-based mCT, Biomaterials, 2011, 32: 8506-8517. Wenjie Dong , Yongsheng Li*, Dechao Niu , Zhi Ma , Jinlou Gu , Yi Chen , Wenru Zhao ,Xiaohang Liu , Changsheng Liu , and Jianlin Shi*, Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy, Adv. Mater. 2011, 23, 5392–5397. Qi Gan, Xunyu Lu, Yuan Yuan, Jiangchao Qian, Huanjun Zhou, Xun Lu, Jianlin Shi, Changsheng Liu*, A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica, Biomaterials, 2011, 32: 1932-1942. Yuan Yuan, Changsheng Liu*, Jiangchao Qian, Jing Wang, Yuan Zhang, Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells, Biomaterials, 2010, 31:730-740. Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu*, Hierarchically microporous/macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration, Biomaterials, 2010, 31:1260-1269. Chenglong Dai, Changsheng Liu*, Jie Wei, Hua Hong, Qinghui Zhao, Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control, Biomaterials, 2010, 31:7620-7630. Yan Sheng, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou, Feng Xu，Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials, 2009, 30: 2340-2348. Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su, Changsheng Liu*, Preparation and characterization of bioactive mesoporous wollastonite – Polycaprolactone composite scaffold. Biomaterials, 2009,30:1080-1088. Huanjun Zhou, Jiangchao Qian, Jing Wang, Wantong Yao, Changsheng Liu*, Jianguo Chen, Xuehua Cao，Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N,6-O-sulfated chitosan in vitro and in vivo，Biomaterials，2009,30:1715-1724. Chenglong Dai, Yuan Yuan, Changsheng Liu*, Jie Wei, Hua Hong, Xiaosheng Li, Xiaohua Pan, Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control, Biomaterials, 2009, 30: 5364-5375. Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Development of mussel adhesive polypeptide mimics coating for in-situ inducing re-endothelialization of intravascular stent devices, Biomaterials, 2009, 30 :2764-2773. Jing Wang, Changsheng Liu*, Xin Lu, Min Yin, Copolypeptides of 3,4-Dihydroxypheny- lalanine and L-lysline to Mimic Marine Adhesive Protein, Biomaterials, 2007, 28:3456-3468. Jian Zhao, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Xiaoqian Shan, Yan Sheng, Fan Wu, Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers, Biomaterials, 2007, 28:1414-1422. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Rheological Properties of Concentrated Aqueous Injectable Calcium Phosphate Cement Slurry, Biomaterials, 2006, 27: 5003-5013. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Effects of the Granularity of Raw Materials on the Hydration and Hardening Process of Calcium Phosphate Cement, Biomaterials, 2003,24: 4103-4113. Changsheng Liu*, Wei Gai, Songhua Pan, Zisheng Liu, The Exothermal Behavior in the Hydration Process of Calcium Phosphate Cement, Biomaterials, 2003, 24:2995- 3003. Changsheng Liu*, Yue Huang, Jinhua Cui, Kinetics of Hydroxyapatite Precipitation at pH 10 to 11, Biomaterial, 2001, 22:301-306. Jing Wang, Changsheng Liu*, Yufei Liu, Shuo Zhang, Double-Network Interpenetrating Bone Cement via in situ Hybridization Protocol, Advanced Functional Materials, 2010, 20: 3997-4011.

承担项目 截至2017年11月，刘昌胜作为项目负责人，先后承担国家重大科学研究计划项目、国家自然科学基金重点及面上项目、“863”项目、教育部高等学校学科创新引智计划和教育部创新团队项目等，国家重大科学研究计划项目首席科学家。 科研成果奖励 截至2017年11月，刘昌胜先后获得国家自然科学奖二等奖（2014年度）、国家科技进步二等奖（2003年度）等多项科技奖励。获授权发明专利38项（其中美国授权专利4项）。